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. 2023 Jan 18;12:1096211. doi: 10.3389/fcimb.2022.1096211

Figure 3.

Figure 3

Serum IgG responses against distinct, genetically different P. copri strains in individuals at risk of RA, new onset rheumatic patients and patients with chronic RA. (A) IgG responses against the different P. copri strains RPC01, HDD04, HDE04, and HDD05 in serum samples of seronegative, symptom-free first degree relatives (FDR 1, n=42), individuals with RA specific autoantibodies (FDR 2, n=40), individuals with RA specific symptoms (FDR 3, n=38) and chronic RA patients (cRA, n=45) as well as in patients with non-rheumatic disease (NRD, n=34) or new onset of rheumatoid arthritis (RA, n=13), psoriatic arthritis (PsA, n=28), and axial spondyloarthritis (axSpA, n=11). (B) Correlation matrix showing Spearman’s correlation coefficient (r) of serum IgG responses against the P. copri strains RPC01, PDSM, HDD04, HDE04, and HDD05, P value of all comparisons < 0.0001 (****). (C) Averaged serum IgG responses against P. copri strains, independent of disease grouping, data analyzed using Friedman test. Data indicates mean ± SD, ****p < 0.0001, not significant if not further indicated.