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. 2023 Jan 31;6:127. doi: 10.1038/s42003-023-04489-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Map of Africa indicating approximately the native range of Xenopus laevis (modified from Furman et al., 2015) and three natural parks (numbers) located in this region. b Mean temperature data taken from the indicated natural parks including warm [hot days (filled triangles) and mean daily maximum (filled squares)] and cold conditions [cold nights (empty triangles) and mean daily minimum (empty squares)]. The mean temperature variation in June and July was used to devise a cooling paradigm (24 °C to 6 °C) that mimics the temperatures experienced by Xenopus in their native environment during the coldest months of winter (rectangle).