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. 2023 Jan 31;13:1711. doi: 10.1038/s41598-023-28635-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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RNA disruption induced by multiple chemotherapy agents in different cell lines. A2780 (a), K562 (b), MDA-MB-231 (c) and A375 (d) cells were exposed to various chemotherapy agents for 72 h. Total RNA was isolated from cells following drug treatment, and RNA disruption was analyzed using the RDA. Data are presented as means ± standard deviation, with individual data points shown in red. Groups labelled with an asterisk possess a normalized RDI that is significantly greater than that of the untreated control (blue dotted line). See Supplementary Table S1 for detailed results of each statistical test. DOX doxorubicin, EPI epirubicin, ETOP etoposide, CBN carboplatin, CIS cisplatin, TAX paclitaxel, DXL docetaxel, VIN vincristine, IRN irinotecan, PBC palbociclib.