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. 2023 Jan 31;13:1728. doi: 10.1038/s41598-023-28165-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) During training to locate a visible platform in the water maze, E3-HL male mice swam faster than E3-TR male mice. *p = 0.015. (B) During visible platform training, E3-TR mice located the visible platform faster than E3-HL mice. ***p = 0.001. (C) During visible platform training, E3-TR mice showed a lower cumulative distance to the platform location that E3-HL mice. *p = 0.023. (D) In the probe trial (platform removed), there was a model × sex interaction for cumulative distance to the target location. There was a trend towards a greater cumulative distance to the target location in E3-HL than E3-TR females. ^#p = 0.0651. (E) There was also a model x sex interaction for the number of crosses over the platform location. In females, E3-HL mice crossed the platform location less than E3-TR mice. *p = 0.0408. (F) The latency to first reach the platform location was higher in E3-HL than E3-TR mice. *p = 0.039. The behavioral testing of the mice was performed at 7 months of age.