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. 2023 Jan 31;13:1728. doi: 10.1038/s41598-023-28165-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Males showed a higher percent spontaneous alternation than females. ^op = 0.018. (B) E3-HL showed more arm entries than E3-TR mice. *p = 0.023. Females showed more arm entries than males. ^oop = 0.003. (C) There was a trend towards a higher percent entries of E3-HL than E3-TR mice in the novel arm of the spatial Y maze. ^#p = 0.070. (D) There was a trend towards a model × day interaction for activity levels in the spatial Y maze (F(1, 35) = 3.547, p = 0.068). The behavioral testing of the mice was performed at 7 months of age.