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. 2023 Jan 31;13:1728. doi: 10.1038/s41598-023-28165-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) During fear learning, prior to the first tone, E3-HL mice showed higher activity levels than E3-TR mice. *p = 0.035). (B) Freezing levels during the tones were lower in E3-HL than E3-TR mice. *p = 0.037. (C) The response to the shocks was lower in E3-HL than E3-TR mice. *p = 0.011. In males, there was also a lower response to the shocks in E3-HL than E3-TR mice **p = 0.0087. (D) Freezing levels between the tone-shock intervals were lower in E3-HL than E3-TR mice. **p = 0.006. In males, freezing levels during the ISIs were lower in HL-E3 than E3-TR mice. *** p = 0.0017. (E) During the contextual fear memory test, freezing levels were lower in E3-HL than E3-TR mice. ****p < 0.001. (F) In the cued fear memory, freezing levels were also lower in E3-HL than E3-TR mice. ****p < 0.001. The behavioral testing of the mice was performed at 7 months of age.