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. 2023 Jan 31;13:1728. doi: 10.1038/s41598-023-28165-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) In E3-HL mice, percent time spent in the center of the open field positively correlated with the discrimination index in the object recognition test. (B) In E3-TR mice, percent time spent in the center of the open field also positively correlated with the discrimination index in the object recognition test. (C) In E3-TR mice, the percent time spent in the center of the open positively correlated with activity levels. (D) In E3-TR mice, the percent time spent in the center of the open negatively correlated with percent freezing during the pre-tone period in the cued fear memory test. (E) In E3-HL mice, distance moved on the first day of open field testing negatively correlated with the percent time freezing during the second tone during fear learning. (F) In E3-HL mice, distance moved on the first day of open field testing negatively correlated with the percent freezing in the contextual fear memory test.