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. 2023 Jan 18;10:986107. doi: 10.3389/fcell.2022.986107

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Copyright © 2023 Ernst, Bidwell, Dora, Thomas and Kamdar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Human induced pluripotent stem cell cardiomyocytes are immature but reflect human heart development. Insights from cardiac morphogenesis has facilitated differentiation of hiPSC to hiPSC-CMs. Currently, hiPSC-CMs are immature compared to adult human cardiomyocytes, but further strategies for maturation may advance the maturity of hiPSC-CMs towards an adult phenotype.