TABLE 1.
Research programs and key information about their populations, protocols, and goals.
| Program name | Enrollment population | Diversity focus | Enrollment setting(s) | Key goals |
|---|---|---|---|---|
| Programs funded via Cancer Moonshot’s initiative for direct patient engagement | ||||
| Cancer Moonshot Biobank (National Cancer Institute, 2022a) | Adolescents or adults diagnosed with 1 of 7 locally advanced or metastatic cancers | Rural, medically underserved; racial and ethnic minorities | NCORP | Accelerate research on drug resistance and sensitivity |
| MyPART Network (National Cancer Institute, 2022e) | Children, teens, and young adults with solid rare tumors | Not a specific focus | Remote; NIH Clinical Center | Accelerate treatment discovery for tumors without cures |
| NCI-CONNECT (National Cancer Institute, 2022f) | Adults with 12 rare central nervous system cancers | Not a specific focus | Remote; NIH Clinical Center | Improve understanding, standards of care, and patient outcomes |
| PE-CGS Network (National Cancer Institute, 2022g) | Children and adults with rare, highly lethal, early onset, high disparities in incidence and/or mortality, or cancers in understudied populations | Rural and medically underserved, low literacy, racial and ethnic minorities | Remote; Academic and non-academic medical centers | Generate new discoveries and transform engagement in cancer genomics |
| Programs external to the Cancer Moonshot’s initiative for direct patient engagement | ||||
| All of Us Research Program (All of Us Research Program, 2021) | All adults (healthy or with any disease) | Persons underrepresented in biomedical research | Remote; Academic and non-academic medical centers | Enable a new era of medicine through research, policies, and technology |
| Connect for Cancer Prevention Study (National Cancer Institute, 2022d) | Adults aged 40–65 without a history of cancer | Racial and ethnic minorities; rural, and medically underserved | Academic and non-academic medical centers | Improve understanding of cancer causes and prevention |
| CCDI (National Cancer Institute, 2022c) | Children, adolescents and young adults with any cancer | All children with cancer | Academic medical center | Speed diagnosis and inform treatment |
| CSER II a (CSER, 2022a) | Children with cancer; adults at risk for hereditary cancer | Racial and ethnic minorities, low SES medically underserved | Academic and non-academic medical centers; outpatient clinic | Understand integration of genomics in clinical care of diverse individuals |
| Count Me In(Count Me In, 2022) | Children, adults with any cancer | Persons with rare cancer | Remote | Accelerate biomedical research through direct patient engagement |
| eMERGE Network (eMERGE Network, 2022) | Children, adults with cancers represented in patient population | Persons of diverse ancestry | Academic medical centers | Combine biobanks with EMRs for large scale genetic research |
a
Reporting on two (of seven) CSER II consortium projects that are focused on cancer.
Abbreviations: CCDI, Childhood cancer data initiative; CSER, Clinical sequencing evidence-generating research (CSER) Consortium; eMERGE, Electronic medical records and genomics (eMERGE) network; MyPART, My pediatric and adult rare tumors network; NCI CORP, National cancer institute community oncology research program; NCI CONNECT, NCI comprehensive oncology network evaluating rare central nervous system tumors; PE-CGS, Participant engagement and cancer genome sequencing (PE-CGS) network.