Table 1.

PICOS criteria for study selection

Parameter	Inclusion	Exclusion
Patients	Diagnosis of PTSD; Age ≥ 18 years	Presence of psychiatric comorbidities except major depressive disorder
Intervention	Quetiapine, any dose as monotherapy or augmenting agent (sequential therapy)	Initial combination therapy including quetiapine and other drugs
Comparator	None or placebo or other active treatments
Outcomes	Quantitative or qualitative evaluation of overall or specific symptoms of PTSD
Study design	Case reports, case series, retrospective, prospective, cohort, cross sectional studies, randomized and non-randomized controlled trial	Reviews, expert opinion, comments, conference report, post-hoc studies, study published in any other language than English

PICOS, Population, Intervention, Comparison, Outcomes and Study; PTSD, posttraumatic stress disorder.