Table 2.
Changes in estimated mean levels of continuous clinical endpoints over time.
| Change in | Visit | Estimated mean and 95% CI | Estimated mean difference from T0 and 95% CI | Within group p-value* |
|---|---|---|---|---|
| HbA1c (%) | T0 | 7.77 | ||
| (7.65;7.89) | ||||
| T3 | 7.32 | -0.45 | <0.0001 | |
| (7.11;7.52) | (-0.64;-0.26) | |||
| T6 | 6.87 | -0.9 | <0.0001 | |
| (6.74;7.01) | (-1.04;-0.76) | |||
| T12 | 6.82 | -0.96 | <0.0001 | |
| (6.7;6.94) | (-1.09;-0.82) | |||
| FBG (mg/dl) | T0 | 159.77 | ||
| (155.07;164.47) | ||||
| T3 | 138.85 | -20.92 | <0.0001 | |
| (132.56;145.14) | (-28.06;-13.78) | |||
| T6 | 133.53 | -26.24 | <0.0001 | |
| (128.82;138.24) | (-32.25;-20.23) | |||
| T12 | 134.01 | -25.76 | <0.0001 | |
| (129.3;138.73) | (-31.57;-19.94) | |||
| Body weight (Kg) | T0 | 92.1 | ||
| (90.41;93.78) | ||||
| T3 | 91.11 | -0.99 | 0.22 | |
| (89.09;93.13) | (-2.57;0.59) | |||
| T6 | 88.67 | -3.43 | <0.0001 | |
| (86.76;90.59) | (-4.51;-2.34) | |||
| T12 | 88.41 | -3.68 | <0.0001 | |
| (86.61;90.22) | (-4.93;-2.44) | |||
| BMI (Kg/m2) | T0 | 32.62 | ||
| (32;33.25) | ||||
| T3 | 32.1 | -0.53 | <0.0001 | |
| (31.45;32.74) | (-0.69;-0.36) | |||
| T6 | 31.64 | -0.99 | <0.0001 | |
| (31;32.27) | (-1.19;-0.79) | |||
| T12 | 31.25 | -1.38 | <0.0001 | |
| (30.61;31.88) | (-1.62;-1.13) | |||
| SBP (mmHg) | T0 | 132.41 | ||
| (130.86;133.96) | ||||
| T6 | 130.09 | -2.32 | 0.03 | |
| (127.92;132.26) | (-4.43;-0.2) | |||
| T12 | 130.18 | -2.22 | 0.05 | |
| (128.04;132.32) | (-4.49;0.04) | |||
| DBP (mmHg) | T0 | 79.79 | ||
| (78.86;80.72) | ||||
| T6 | 78.53 | -1.27 | 0.06 | |
| (77.31;79.75) | (-2.59;0.06) | |||
| T12 | 79.59 | -0.2 | 0.78 | |
| (78.37;80.82) | (-1.56;1.17) | |||
| Total cholesterol (mg/dl) | T0 | 167.07 | ||
| (162.87;171.28) | ||||
| T6 | 155.61 | -11.47 | <0.0001 | |
| (149.86;161.35) | (-17.19;-5.75) | |||
| T12 | 157.99 | -9.09 | 0.0004 | |
| (152.85;163.12) | (-14.08;-4.09) | |||
| LDL cholesterol (mg/dl) | T0 | 91.13 | ||
| (87.05;95.21) | ||||
| T6 | 81.88 | -9.25 | 0.0002 | |
| (77.03;86.73) | (-14.05;-4.45) | |||
| T12 | 84.69 | -6.44 | 0.01 | |
| (80.14;89.23) | (-11.37;-1.51) | |||
| HDL cholesterol (mg/dl) | T0 | 45.33 | ||
| (44.18;46.49) | ||||
| T6 | 44.99 | -0.34 | 0.57 | |
| (43.49;46.49) | (-1.52;0.83) | |||
| T12 | 46.13 | 0.79 | 0.16 | |
| (44.79;47.46) | (-0.31;1.89) | |||
| Triglycerides (mg/dl) | T0 | 166.51 | ||
| (154.3;178.71) | ||||
| T6 | 153.01 | -13.49 | 0.07 | |
| (140.62;165.4) | (-27.9;0.91) | |||
| T12 | 147.18 | -19.33 | 0.001 | |
| (135.33;159.03) | (-31.1;-7.56) | |||
| eGFR (ml/min*1.73m2) | T0 | 77.57 | ||
| (75.52;79.61) | ||||
| T6 | 77.1 | -0.47 | 0.44 | |
| (74.98;79.22) | (-1.65;0.72) | |||
| T12 | 77.92 | 0.36 | 0.55 | |
| (75.77;80.07) | (-0.81;1.52) | |||
| ACR (mg/g) | T0 | 84.39 | ||
| (27.31;141.47) | ||||
| T6 | 34.26 | -50.13 | 0.18 | |
| (-15.48;84) | (-123.76;23.49) | |||
| T12 | 49.29 | -35.09 | 0.33 | |
| (2.9;95.69) | (-105.91;35.72) | |||
| HOMA-B (%) | T0 | 40.28 | ||
| (32.05;48.52) | ||||
| T6 | 57.81 | 17.53 | <0.0001 | |
| (48.96;66.66) | (14.21;20.85) |
HbA1c, Glycated haemoglobin; FBG, Fasting blood glucose; BMI, body mass index; SBP, Systolic blood pressure; DBP, Diastolic blood pressure; HDL, High-density lipoprotein; LDL, Low-density lipoprotein; eGFR, estimated glomerula filtration rate; ACR, albumin creatinine ratio; HOMA-B, homeostatic model assessment for β-cell function; 95% CI, 95% confidence intervals.
*Paired t-test derived from linear mixed models for repeated measurements. Values in bold are statistically significant