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. 2023 Jan 18;14:1069331. doi: 10.3389/fphar.2023.1069331

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Copyright © 2023 Huang, Ding, Xu, Xi, He, Luo, Guo and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Global differentially expressed proteins (DEPs) in the spinal dorsal horn (SDH) of rats following chronic constriction injury (CCI). Rats developed neuropathic pain after CCI surgery, as evidenced by the decrease in the paw withdrawal mechanical threshold (PWMT) (A) and the paw withdrawal thermal latency (PWTL) (B) (n = 8, ***p < .001, two-way ANOVA with repeated measures followed by Bonferroni’s multiple comparisons test). (C) The quality control results of mass spectrometry data. The horizontal coordinate indicates the peptide length, and the vertical coordinate indicates the number of peptides. (D) A significant difference in nuclear proteins was found between the sham and CCI groups on day 1. (E) A significant difference in nuclear proteins was found between the sham and CCI groups on day 7. The horizontal coordinate represents the log2 value (Fold Change), and the vertical coordinate represents −lg (p-value). Upregulated genes are shown in red, downregulated genes are shown in blue, and genes with no significant differences are shown in gray. (F) The unique or shared DEPs in each of the paired groups. (G) The differences in 173 nuclear proteins at 1 and 7 days after CCI compared with those in the sham group.