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. 2023 Jan 18;14:1069331. doi: 10.3389/fphar.2023.1069331

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Copyright © 2023 Huang, Ding, Xu, Xi, He, Luo, Guo and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Downregulation of STAT2 induced nociceptive hypersensitivity. (A) The specific location of the intraspinal injection of si-STAT2. (B) The time points of si-STAT2 administration in naïve rats. (C,D) Nuclear expression of STAT2 was reduced in the spinal dorsal horn (SDH) after si-STAT2 injection compared with those in rats treated with normal saline (NS) or the corresponding negative control (si-NC) (n = 4, **p < .01, *p < .05, one-way ANOVA followed by Bonferroni’s multiple comparisons test). (E,F) Injection of si-STAT2 decreased the paw withdrawal mechanical threshold (PWMT) (E) and paw withdrawal thermal latency (PWTL) (F) in naïve rats from days 3–5 (si-STAT2 vs. si-NC, n = 8, **p < .01, ***p < .001, two-way ANOVA with repeated measures followed by Bonferroni’s multiple comparisons test).