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. 2023 Jan 18;14:1069331. doi: 10.3389/fphar.2023.1069331

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Copyright © 2023 Huang, Ding, Xu, Xi, He, Luo, Guo and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Downregulation of STAT2 promoted microglial activation and Tnf and Il1b expression. (A) Negative control (si-NC) rats had resting microglia with a ramified morphology, whereas si-STAT2 rats had activated microglia with an amoeboid morphology. (n = 3, scale bar = 100 µm). (B) si-STAT2 treatment increased the number of microglia in the spinal dorsal horn (SDH) (n = 3, *p < .05, Mann-Whitney test). (C,D) Expression of Il1b and Tnf mRNA was significantly increased in the SDH after intraspinal injection of si-STAT2 (n = 6, **p < .01, *p < .05, two-tailed unpaired Student’s t-test).