Table 2.

TGI and XL092 dose exposure across four xenograft models.

Tumor model	Dose (mg/kg/day), duration (days)	Tumor growth inhibition	Tumor regression (%)	P
NCI-H441	1, 21	68.3	–	–
NCI-H441	3, 21	–	5.6	0.0115
NCI-H441	10, 21	–	67.7	<0.0001
NCI-H441	30, 21	–	72.1	<0.0001
NCI-H441	60, 21	–	86.1	<0.0001
Hs 746T	1, 12	10.1	–	–
Hs 746T	3, 12	35.6	–	0.0015
Hs 746T	10, 12	70.2	–	<0.0001
Hs 746T	30, 12	94.9	–	<0.0001
SNU-5	3, 14	54.2	–	0.0052
SNU-5	10, 14	94.7	–	<0.0001
MDA-MB-231	3, 14	73.6	–	0.0003
MDA-MB-231	10, 14	78.6	–	0.0002