FIGURE 3.
Quantitative assessment of anti‐S antibody titers. (A) Anti‐S antibody (infection/vaccination‐induced antibody) titers by COVID‐19 vaccination status and past SARS‐CoV‐2 infection history determined by self‐reported history of past infection or presence of the infection‐induced antibodies. The titers between groups with different vaccination status and past infection history were compared using Kruskal–Wallis test with Dunn's test. (B) Anti‐S antibody titers by vaccination status and age group. The titers between 20–29 age group and older age groups with same vaccination status were compared using Kruskal–Wallis test with Dunn's test. (C) Anti‐S antibody titers by underlying disease among individuals who received two doses of COVID‐19 vaccines without evidence of past infection. COPD; chronic obstructive pulmonary disease. The titers between those with and without comorbidities were compared using Kruskal–Wallis test with Dunn's test. (D) Anti‐S antibody titers by underlying disease among individuals who received three doses of COVID‐19 vaccines without evidence of past infection. The titers between those with and without comorbidities were compared using Kruskal–Wallis test with Dunn's test; ns, not significant. (E) Anti‐S antibody titers by time since the second dose. The titers between those who were after 0–3 months since second dose and those with longer time than 4 months since the second dose or those with the third dose were compared using Kruskal–Wallis test with Dunn's test. A black bar on each plot indicates geometric mean with 95% confidence interval. Anti‐S antibody; anti‐spike antibodies. The horizontal gray bar line with “3 vac” or “2vac” label indicates geometric mean titer of anti‐S antibody titers of individuals who received three doses or two doses of COVID‐19 vaccines without evidence of past infection, respectively. The horizontal dotted line without any label indicates manufacturer‐determined cutoff. For (C), and (D), groups are not mutually exclusive. Statistical significance: ns, not significant, ***p < 0.001, ****p < 0.0001