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PTA for oral amoxicillin and ciprofloxacin. (a) PTA for oral amoxicillin 750 mg, defined as achieving an amoxicillin plasma concentration above the MIC during half of the dosing interval (50%T>MIC); (b) PTA for oral ciprofloxacin 500 mg, defined as achieving an AUC0–24/MIC ratio ≥125 (calculated as AUC0–12 multiplied by 2). PTA was calculated for a range of MICs, for the febrile phase and the afebrile phase separately.
