Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 10;29(2):195–206. doi: 10.1093/ibd/izac212

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 2. — PDO-derived monolayers display consistent responses to media for gene expression and physiological cell-type signatures. A, PCA analysis of biological replicates of control donor-derived monolayers (upper panel) and IBD-PDO-derived monolayers (lower panel) grown in media specified. B, Control donor- and IBD-PDO-derived monolayers differentially expressed genes. Red symbols are significantly different between conditions. C, Heat map depicting expression of epithelial cell-type related genes. D, Epithelial cell-type signatures after differentiation are represented as fold-change relative to undifferentiated.