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. 2022 Nov 10;29(2):195–206. doi: 10.1093/ibd/izac212

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© 2022 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Intestinal cells respond differently to plating in organoid vs monolayer formats. A, PCA analysis of organoid and monolayer formats. B, Genes differentially expressed between monolayers and organoids. Red symbols are significantly different between conditions (FDR < .01). C, Differentially expressed pathways between monolayers and organoids. D, Normalized expression of selected epithelial genes. Box plots denote the average and standard deviation of 3 technical replicates of 2 to 3 independent biological replicates per condition. Relevant statistics were performed using ttest with Bonferroni multiple comparison correction (*P < .05, **P < .01, ***P < .001, ****P < .0001).