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. 2022 Dec 21;42(3):e111998. doi: 10.15252/embj.2022111998

Figure 5. WRN helicase core and RQC domains are responsible for cruciform DNA unfolding.

Figure 5

  1. Primary structure of WRN. Full‐length and truncation WRN variants are shown.
  2. Recombinant full‐length and truncation WRN variants used in this study are shown. The gel was stained with Coomassie Brilliant blue.
  3. Quantitation of DNA unwinding from assays such as shown in (EV5). Averages shown; n = 3 technical replicates; error bars, SEM.
  4. Cruciform unfolding assays with increasing concentrations of WRN variants.
  5. Quantitation of assays such as shown in (D). Averages shown; n = 3 technical replicates; error bars, SEM.