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. 2022 Dec 9;42(3):e111065. doi: 10.15252/embj.2022111065

Figure 2. Cryo‐EM structure of ABCA7DIGITONIN .

Figure 2

  1. Cryo‐EM map of human ABCA7DIGITONIN at 3.9 Å with density for protein shown in green (0.013 contour) and extraneous density likely belonging to detergent shown in pink (0.013 contour).
  2. Cryo‐EM structure of human ABCA7DIGITONIN shown in ribbon format with each half colored differently (blue and green).
  3. TMD lumen of ABCA7DIGITONIN with density for bulk micelle shown in white at 0.015 contour where detergent density inside TMDs disappears. Sticks for unmodeled detergent molecules are shown for which density is visible at the lower contour of 0.013.
  4. TMD lumen of ABCA7PE with density (0.035 contour) for TMD lipids (pink) and peripherally associated ordered lipids (white) shown.
  5. Same as (D) with higher density contour of 0.046 where density of peripherally associated lipids is absent but that of luminal lipids remains.