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. 2022 Dec 9;42(3):e111065. doi: 10.15252/embj.2022111065

Figure 4. Comparison of open and closed conformations of ABCA7.

Figure 4

  1. Overall structural alignment of the three ABCA7 conformations.
  2. Overall alignment of the three ABCA7 conformations showing only TMD1 and TMD2 viewed from the extracellular side using the TMD1‐NBD1 pair as an alignment reference. TMs lining the TMD pathway are numbered, and modeled lipid acyl chains are shown as outlined white spheres.
  3. Same as panel (B), viewed from the cytoplasmic side with Cα atoms of gate forming residues shown as spheres.
  4. Individual alignments of rigid body pairs TMD1‐NBD1, TMD2‐NBD2, and ECD along with the Root mean square deviations (RMSD) of aligned atoms of ABCA7PE versus ABCA7EQ‐ATP and ABCA7DIGITONIN.