Table 2.
Associations between Previously Identified Pulmonary Fibrosis–associated Genetic Loci, Single-Protein Measurements, and Interstitial Lung Abnormalities
| SNPs and ILAs (Previously Reported) |
SNPs and Proteins |
Proteins and ILAs |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| rsID | Chromosomal Location | Nearest Gene | OR | P Value | Protein | β (SE) | P Value | OR | P Value |
| rs73199442 | 3q13 | FCF1P3 | 1.68 (1.39–2.02) | 5 × 10−8 | – | – | – | – | – |
| rs6886640 | 5q12 | IPO11 | 1.28 (1.18–1.41) | 4 × 10−8 | – | – | – | – | – |
| rs7744971 | 6q15 | HTR1E | 1.26 (1.16–1.37) | 1 × 10−7 | – | – | – | – | – |
| rs35705950 | 11p15 | MUC5B | 1.97 (1.74–2.22) | 3 × 10−27 | SFTPB | 0.26 (0.030) | 8 × 10−18 | 3.71 | 4.28 × 10−67 |
| rs2609255 | 4q22 | FAM13A | 1.18 (1.07–1.29) | 5 × 10−4 | – | – | – | – | – |
| rs2076295 | 6p24 | DSP | 1.14 (1.05–1.2) | 0.001 | – | – | – | – | – |
| rs2034650 | 15q15 | IVD | 1.08 (0.99–1.17) | 0.07 | – | – | – | – | – |
| rs12610495 | 19p13 | DPP9 | 1.14 (1.03–1.26) | 0.01 | N/A | N/A | N/A | N/A | N/A |
| rs6793295 | 3q26 | LRRC34 | 1.06 (0.97–1.15) | 0.2 | N/A | N/A | N/A | N/A | N/A |
| rs1981997 | 17q21 | MAPT | 1.16 (1.03–1.30) | 0.01 | – | – | – | – | – |
| rs2736100 | 5p15 | TERT | 1.03 (0.95–1.12) | 0.44 | THPO | 0.11 (0.019) | 4 × 10−9 | 0.77* | 1.39 × 10−4 |
| 1.19* | 3.93 × 10−3 | ||||||||
| rs11191865 | 10q24 | OBFC1 | 1.03 (0.95–1.12) | 0.46 | – | – | – | – | – |
| rs1278769 | 13q34 | ATP11A | 1.04 (0.95–1.15) | 0.37 | F7 | −0.13 (0.020) | 6 × 10−11 | 0.91 | 0.17 |
| rs62025270 | 15q25 | AKAP13 | 1.09 (0.99–1.20) | 0.08 | – | – | – | – | – |
| rs4727443 | 7q22 | LOC1001 28334/LOC1053 75423 | 0.95 (0.87–1.03) | 0.19 | PILRA | −0.50 (0.019) | 2 × 10−151 | 0.97* | 0.66 |
| 0.97* | 0.56 | ||||||||
| 1.30* | 1.20 × 10−5 | ||||||||
| 1.21* | 1.69 × 10−3 | ||||||||
| 1.07* | 0.26 | ||||||||
Definition of abbreviations: AGES-Reykjavik = Age, Gene/Environment Susceptibility–Reykjavik; CI = confidence interval; ILA = interstitial lung abnormality; OR = odds ratio; PILRA = Paired Immunoglobin Like Type 2 Receptor Alpha; SFTPB = surfactant protein B; SOMAmers = Slow-Off rate Modified Aptamers; THPO = thrombopoietin.
SNPs and ILAs: the associations between the listed SNPs and ILAs as previously reported (8). SNPs and proteins: the associations between the listed SNPs and proteins in the AGES-Reykjavik cohort, adjusted for age, sex, pack-years of smoking, and smoking at study entry. Proteins with an association with a P value < 5 × 10−8 are shown. Proteins and ILAs: the associations between shown proteins and ILAs, calculated with logistic regression adjusted for age, sex, pack-years of smoking, and smoking at study entry. N/A indicates data for SNP not available in AGES-Reykjavik.
Data shown for multiple SOMAmers binding to the same protein.