Table 4.

Clinical signs at admittance associated with death and survival (N=1521)

				Univariableb			Multivariablec
	Total Na	Survival	Death	OR	95% CI	p	aOR	95% CI	p
Total, N	1521	1484	37
Clinical signs at admittance
GCS score, median (IQR)	1232	15 (0)	14 (7–15)	0.72	0.65 to 0.78	<0.0001	0.76	0.63 to 0.92	0.005
Abnormal breathingd	1513	123 (8)	18 (49)	10.48	5.36 to 20.50	<0.0001	6.81	1.76 to 26.40	0.006
Low urinary output (<750 ml)	1196			3.32	2.35 to 4.69	<0.0001	2.55	1.34 to 4.85	0.004
>750 ml		988 (85)	13 (48)
500–750 ml		114 (12)	4 (15)
400–500 ml		23 (2)	3 (11)
< 400 ml		14 (1)	7 (26)
Abdominal tendernesse	1516	108 (7)	8 (22)	3.52	1.57 to 7.88	0.002	5.76	1.27 to 26.10	0.023
Saturation <95%	1257	264 (22)	15 (50)	3.65	1.76 to 7.56	<0.0001	3.52	0.97 to 12.72	NS
Pulse rate, median (IQR)	1497	92 (84–100)	105 (87–119)	1.02	1.00 to 1.04	0.014	0.98	0.95 to 1.01	NS
Spontaneous bleedingf	1508	13 (1)	5 (14)	17.68	5.95 to 52.55	<0.0001	0.47	0.02 to 14.12	NS
Icterus	1514	106 (7)	13 (35)	7.01	3.47 to 14.15	<0.0001	3.63	0.72 to 18.25	NS
Neck stiffnessg	1514	26 (2)	3 (8)	4.92	1.42 to 17.06	0.012	NA	NA	NA
Edemah	1515	89 (6)	11 (30)	6.63	3.17 to 13.86	<0.0001	0.94	0.16 to 5.45	NS
Pallor	1515	320 (22)	18 (50)	3.62	1.86 to 7.04	<0.0001	3.75	0.79 to 17.74	NS
Conjunctival congestion	1500	71 (5)	6 (17)	4.06	1.63 to 10.10	0.003	0.36	0.02 to 6.17	NS
Eschar	1476	38 (3)	3 (8)	3.35	0.99 to 11.41	NS
Temp F, median (IQR)	1425	101 (99–102)	99 (99–100)	1.00	0.98 to 1.02	NS
BP systolic, median (IQR)	1470	110 (100–120)	110 (94–120)	1.00	0.98 to 1.02	NS
Respiratory rate, median (IQR)	1487	24 (22–26)	24 (20–30)	1.04	0.99 to 1.09	NS
Joint tenderness	1520	46 (3)	3 (8)	2.76	0.82 to 9.30	NS
Joint swelling	1519	23 (2)	1 (3)	1.75	0.23 to 13.4	NS
Rash	1502	40 (3)	1 (3)	0.99	0.13 to 7.40	NS
Coated tongue	1504	126 (9)	4 (11)	1.38	0.48 to 3.96	NS
Lymphadenopathy	1499	85 (6)	2 (6)	0.02	0.24 to 4.31	NS
Spleen palpable	1490	110 (8)	2 (6)	0.72	0.17 to 3.03	NS
Liver palpable	1487	149 (10)	5 (14)	1.41|	0.54 to 3.68	NS
Liver tenderness	1321	39	1	1.07	0.14 to 8.04	NS
Renal angel tenderness	1509	5	0			NS
Ascites	1514	10 (1)	0			NS
Cardiac murmur	1514	5 (0.3)	0			NS

Abbreviations: aOR, adjusted odds ratio; GCS, Glasgow coma scale, score 1–15 and 15 optimal cerebral function; NA, not applicable.

^aTotal number investigated among 1521 patients. Discrepancies due to missing values.

^bUnivariable logistic regression.

^cMultivariable logistic regression, age and gender included.

^dMerged variables “Abnormal breathing pattern” (N=26 and 10), “Adventitious sounds” (N=77 and 13) and “Air entry unequal” (N=51 and 8).

^eMerged variables “Abdominal tenderness” (N=103 and 8), “Abdominal guarding” (N=14 and 2) and “Abdominal rigidity” (N=3 and 1).

^fMerged variables “Spontaneous bleeding” (N=8 and 3), “Bleeding from injection sites” (N=5 and 3) and “Torniquet positive” (N=3 and 0)

^gResults in multivariate analysis not applicable due to sparse data.

^hMerged variables “Facial puffiness” (N=57 and 8) and “Pedal edema” (N=51 and 7).

Missing coded as negative in merged variables for the sake of the analyses.