Table 5.

Microbiological and biochemical findings at admission associated with death and survival (n=1521)

				Univariableb			Multivariablec
	Cases Na	Survival N (%)	Death N (%)	OR	95% CI	p	aOR	95% CI	p
Total	1521	1484	37
Biochemical tests
Leucocytes, median (IQR)	1265	7,6 (5,7–11.0)	15,4 (8.3–22.7)	1.06	1.03 to 1.09	<0.0001	1.07	1.04 to 1.10	<0.0001
Neutrophils, median (IQR)	1307	71 (60–80)	84 (76–89)	1.07	1.04 to 1.11	<0.0001
Platelets, median (IQR)	1367	160 (93–242)	100 (27–182)	0.992	0.988 to 0.997	0.001	0.992	0.987 to 0.997	0.001
Bilirubin total, median (IQR)	476	1.0 (0.6–2.2)	2.3 (0.83–11.3)	1.03	1.00 to 1.06	0.047
Blood urea (median (IQR)	267	25.0 (17.6–39.5)	64.1 (2.7–139.8)	1.01	1.00 to 1.02	0.005
Hemoglobin, median (IQR)	1413	11.4 (9.9–12.8)	10.4 (8.5–12.1)	0.91	0.80 to 1.00	NS
ALT, median (IQR)	707	44 (24–71)	86 (50–167)	1.00	0.99 to 1.00	NS
Creatinine, median (IQR)	873	1.0 (0.8–1.3)	1.8 (1.2–3.1)	1.01	0.97 to 1.06	NS
Microbiological diagnosesd
Malaria	1394	258e (17)	7f (19)	1.12	0.48 to 2.55	NS
Scrub typhus	1410	151 (10)	5 (14)	1.38	0.53 to 3.59	NS
Dengue	1501	236 (16)	4 (11)	0.64	0.23 to 1.83	NS
Leptospirosis	1410	109 (7)	4 (11)	1.53	0.53 to 4.40	NS
Bacteremia	1113	122 (8)	2g (5)	0.64	0.15 to 2.68	NS
Chikungunya	1460	94 (6)	2 (5)	0.85	0.20 to 3.57	NS

Abbreviations: ALT, alanine transaminase; aOR, adjusted odds ratio; NS, not significant.

^aTotal number investigated among 1521 patients. Discrepancies due to missing values.

^bUnivariable logistic regression.

^cMultivariable logistic regression, age and gender included.

Bilirubin and urea were not included in the multivariable analysis due to high number of missing values, and neutrophils was not included due to likely confounding factor.

^dCase definitions described in text. Some patients fulfilled multiple case definitions.

^e P. falciparum, N=110 (7%); P. vivax, N=93 (6%); P. malariae, N=9 (1%); P.f.+P.v., N=27 (2%); P.f.+P.m., N=2; P.v.+P.m., N=1.

^f P. vivax (n=3) and P. falciparum (n=4).

^g S. aureus (n=1) and E. coli (n=1).