Table 6.
Duration of hospitalization and antimicrobial treatment associated with microbiological diagnoses among patients who died (n=37)
| Died | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total Na | Survived | Total died | P . f. | P . v. | P. f + lepto-spirosis | Lepto-spirosis | Bacteremiab | Scrub typhus | Scrub and lepto-spirosis | Scrub and dengue | Dengue | No microbiol. diagnosis | |
| Total, N | 1521 | 1484 | 37 | 2 | 3 | 2 | 1 | 2 | 3c | 1 | 2 | 2 | 19 |
| Duration in hospital, median (IQR), dd | 1270 | 4 (3–5) | 3 (1–4) | ||||||||||
| Antimalarials, n (%) | |||||||||||||
| Artemisinine and/or quinine | 2 | 3 | 2 | ||||||||||
| Artesunate | 233 | 215 (92) | 18 (8) | 3 | 1 | 1 | 1 | 1 | 11 | ||||
| Artemether | 31 | 26 (84) | 5 (16) | 2 | 1 | 2 | |||||||
| Quinine | 21 | 15 (71) | 6 (29) | 2 | 1 | 3 | |||||||
| Chloroquine | 93 | 87 (94) | 6 (7) | 2 | 1 | 3 | |||||||
| Primaquine | 50 | 49 (98) | 1 (2) | 1 | |||||||||
| Mefloquine | 6 | 4 (67) | 2 (33) | 2 | |||||||||
| Sulphadox/pyrimeth | 4 | 3 (75) | 1 (25) | 1 | 1 | 1 | 1 | ||||||
| Antibiotics, n (%) | |||||||||||||
| 3. gen cephalosporin | 971 | 944 (97) | 27 (3) | 2 | 1 | 1 | 2 | 1 | 1 | 1 | 17 | ||
| 2. gen cephalosporin | 38 | 37 (97) | 1 (3) | 1 | |||||||||
| 1. gen cephalosporin | 27 | 26 (96) | 1 (4) | 1 | |||||||||
| Carbapenem | 6 | 6 (100) | 0 | ||||||||||
| Penicillin | 117 | 105 (90) | 12 (10) | 2 | 1 | 1 | 1 | 7 | |||||
| Aminoglycoside | 71 | 63 (89) | 8 (11) | 2 | 1 | 1 | 4 | ||||||
| Piperacillin/tazobactam | 54 | 49 (91) | 5 (9) | 1 | 2 | 2 | |||||||
| Quinolone | 62 | 60 (97) | 2 (3) | 1 | 1 | ||||||||
| Macrolide | 123 | 122 (99) | 1 (1) | 1 | |||||||||
| Tetracycline | 609 | 586 (92) | 23 (4) | 2 | 1 | 1 | 1 | 3 | 1 | 2 | 12 | ||
| Clindamycin | 3 | 2 | 1 | 1 | |||||||||
Total number investigated among 1521 patients. Discrepancies due to missing values.
S. aureus case had received three antibiotics and E. coli case no antibiotics.
One patient was Scrub ELISA positive and IFA negative, but diagnosis confirmed by eschar.
9/32 (28%) died day 1, 6/32 day 2 and 7/32 day 3. Mann Whitney U test p=0.001.