| Molt-4 cells198
|
Dual-aptamer (Sgc8c and ATP aptamers)-functionalized graphene oxide (DAFGO) complex |
Flow cytometry analysis, fluorescence imaging |
High targeting |
Sensitive and selective detection of Molt-4 cells |
| ALL cells199
|
Specific DNA aptamer sgc8c |
Topographic and recognition imaging (TREC) |
High density and homogeneous lateral distribution in ALL-cells |
Sensitive and selective detection of Molt-4 cells |
| CCl-119 cells180
|
Biotinylated aptamers in conjunction with metal-labeled neutravidin |
Mass cytometry, CyTOF experiments |
Differentiating positive, CCL-119, and negative, Ramos cell lines |
Successfully utilized for mass cytometry experiments on par with commercially available antibodies |
| Ramos cells179
|
Aptamer-nanoparticle strip biosensor (ANSB) |
SELEX (systematic evolution of ligands by exponential enrichment) |
Detecting a minimum of 4000 Ramos cells without instrumentation and 800 Ramos cells with a portable strip reader |
A simple, rapid, and low-cost tool for both the qualitative and quantitative detection of cancer |
| T-ALL cells185
|
Aptamer-conjugated magnetic beads (apt-MBs) |
Magnet–QCM system |
The detection limit of 8 × 103 cells mL−1 for human acute leukemia cells |
Required no further labeling of cells, the potential for specific detection of various kinds of cancer cells |
| Ramos cells184
|
Self-assembled aptamer-micelle nanostructure (TDO5-micelle) |
Fluorescence shift |
About 0.005 nM or 5 nM, based on DNA-lipid concentration |
Rapid recognition ability with enhanced sensitivity and low critical micelle concentration |
| CCRF-CEM cells183
|
Single-stranded DNA aptamer |
Gold nanoparticle (Au NP) labeling with backscattered electron (BE) imaging of field emission scanning electron microscopy (FESEM) |
Sensitive and reversible probes to label target biomolecules on cells. |
The high detection sensitivity of the colloidal probe method |
| HL-60 and CEM as AML and ALL cells182
|
Hierarchical assembly of dual aptamer functionalized, multilayered graphene–Au nanoparticle |
Electrodeposition |
The detection limit as low as 350 cells per mL, and a wide linear range |
Diagnostic tool for early detection and classification of human acute leukemia |
| CEM and Ramos cells200
|
QDs-bsb-apt |
Quantifying the fluorescence signal of the QDs |
CEM cells (71.6%) could be detected by employing the QDs-bsb-Sgc8 complex, while FITC-Sgc8 detected 57.5% of cells |
The detection efficiency of QDs-bsb-Sgc8 was 1.2-fold higher than that of the traditional organic dye modified aptamer FITC |
| CCRF-CEM cells201
|
Silver decahedral nanoparticle (Ag10NP)-based FRET (fluorescence resonance energy transfer) sensor (Ag10NP-based FRET sensor (Ag10-Sgc8-F/Q). |
FREF-based methods |
Highly sensitive and specific for CCRF-CEM cell imaging |
Simple, inexpensive, and convenient for target cell imaging. |
| CCRF-CEM cells21
|
Terbium(iii)-aptamer (Tb3+-apt) |
Fluorescence spectrophotometer |
The detection limit of 5 cells per ml of the binding buffer |
Rapid, sensitive, and economical diagnosis of various types of leukemia at the early stage |
| CCRF-CEM cells202
|
ZnO nanodisks(NDs)@g-C3N4 quantum dot conjugation to the Sgc8c aptamer |
Photoelectrochemical (PEC) |
The detection limit down to 20 cell per mL |
Wide detection range, low detection limit, excellent selectivity, and reproducibility |
| ALL186
|
Aptamer-based electrochemical nano-biosensor (graphitic carbon nitride (Au/g-C3N4 /aptamer nanocomposite) |
Gene detection (miRNA-128) |
The limit of detection of 0.0034 fM concentration of miRNA-128 detection |
Needed a short time (about 45 minutes) to detect miRNA-128 as a symptom of the disease |
| CEM cells and Ramos cells203
|
Aptamer-functionalized copolymer/TPdye fluorescent organic dots |
Two-photon imaging |
Tissue imaging up to 210 mm |
A powerful tool for cancer cell-targeted imaging |
