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. 2023 Jan 31;29:17. doi: 10.1186/s10020-023-00614-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — IPA attenuated OA progression in rat model. A–C Representative images of safranin O-fast green and H&E staining of cartilage and synovial sections from different groups. D The total synovitis scores of different groups. E The cartilage OARSI scores of different groups. F–K Immunohistochemistry staining and percentage of positive cells of MMP-3, MMP-13, ADAMTS-5, aggrecan and collagen-II. n = 5, Scale bar = 100 μm. ^**p < 0.01 vs. the control group, ^##p < 0.01 vs. the ACLT group