Table 4.

PD patient only analyses (N = 93)

PD specific factors	Differentially expressed bacterial taxa/predicted pathways		log2 FoldChange	Adjusted p
L-Dopa daily dosage	Phylum	- - - -	- - - -	- - - -
	Genus	- - - -	- - - -	- - - -
	Metacyc pathway	- - - -	- - - -	- - - -
PD Subtypes (PIGD vs. Tremor Dominate + Indeterminate)	Phylum	Proteobacteria	−1.664	0.0045
		Synergistota	−3.436	0.0129
		Verrucomicrobiota	1.327	0.0129
	Genus	- - - -	- - - -	- - - -
	Metacyc pathway	NAD biosynthesis II (from tryptophan)	−10.991	0.0000
PD Duration	Phylum	Synergistota	−0.417	0.0437
	Genus	Pseudomonas	−1.799	<0.0001
		Haemophilus	0.497	0.0005
		Fournierella	1.073	0.0009
		DTU089	0.540	0.0096
		Roseburia	−0.161	0.0155
		Lactobacillus	−0.269	0.0155
	Metacyc pathway	Gallate degradation I	−1.842	<0.0001
		Catechol degradation to 2-oxopent-4-enoate II	−1.643	<0.0001
		Catechol degradation II (meta-cleavage pathway)	−1.715	0.0001
		Methylgallate degradation	−1.184	0.0017
		Gallate degradation II	−1.167	0.0023
		Toluene degradation IV (aerobic) (via catechol)	−0.769	0.0157
UDPRS III	Phylum	- - - -	- - - -	- - - -
	Genus	Senegalimassilia	−0.435	0.0002
		Lachnospiraceae_NK4B4_group	0.491	0.0021
	Metacyc pathway	- - - -	- - - -	- - - -

PD, Parkinson’s disease; TD, tremor dominant; PIGD, postural instability and gait dysfunction; UPDRS, Unified Parkinson’s Disease Rating Scale.