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RB organoids retain the genomic landscape of the parental RB tissue. A Copy number variation profiles of retinoblastoma tissues (T) and the corresponding RB organoids (O) determined by comparative genomic hybridization/single nucleotide polymorphism array. B, C Pathogenic variants (B) and mutant genes (C) determined by whole-exome sequencing. D Summary of tumor laterality and RB forms, and commonly altered genes
