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. 2023 Jan 31;13(1):e068652. doi: 10.1136/bmjopen-2022-068652

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Study flowvhart. The number of patients to be randomised and assigned to one of two treatment arms, on 1.0 mg semaglutide or matching placebo once a weel is 104, with an expected drop-out rate of up to 50% for the 26-week trial period. DXA, dual-energy X-ray absorption; PANSS-6, Positive and Negative Syndrome Scale–Six Items.