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. 2023 Feb 1;21:65. doi: 10.1186/s12967-023-03908-y

Table 2.

The univariate linear regression analysis and multivariate stepwise regression analysis between clinical characteristics and OA diameter and blood flow velocity

Univariate Multivariatea
Variables β (95% CI) P Value* β(95% CI) P Value
Diameter SBP − 0.007 (− 0.011 to − 0.003) 0.001
Homocysteine − 0.016 (− 0.030 to − 0.002) 0.025
WMHs − 0.223 (− 0.375 to − 0.072) 0.005
CMB − 0.263 (− 0.408 to − 0.118) 0.001 − 0.231 (− 0.380 to − 0.082) 0.003
Enlarged perivascular spaces − 0.245 (− 0.400 to − 0.090) 0.003 − 0.226 (− 0.382 to − 0.071) 0.006
Velocityb Ischemic heart disease − 0.529 (− 0.840 to − 0.219) 0.001 − 0.318 (− 0.539 to − 0.097) 0.006
Lacunar infarct − 0.663 (− 0.936 to − 0.391)  < 0.001 − 0.424 (− 0.648 to − 0.200)  < 0.001
WMHs − 0.709 (− 0.959 to − 0.459)  < 0.001 − 0.468 (− 0.692 to − 0.245)  < 0.001
CMB − 0.621 (− 0.892 to − 0.350)  < 0.001

SBP systolic blood pressure, WMHs white matter hyperintensities, CMB cerebral microbleed

*P < 0.05 is significant in univariate linear regression analysis

aSignificant variables in results of the univariate regression were included in the multivariate stepwise regression analysis

bVariables are transformed to natural logarithms