TABLE 2.

Morphology-associated and other cell wall proteins

Protein	Gene	Location	Commentsa	Reference(s)
Morphology associated
4C12 antigen (180 kDa, 260 kDa)		Hyphae	Structural protein?	59, 62, 122, 128, 160, 327
3D9 antigen (110–170 kDa)		Hyphae	Structural protein?	324, 325
DC3:H10 antigen		Hyphae	Present in complex with other proteins	87, 300
Hwp1p (34 kDa)	HWP1	Hyphae	N-terminal signal sequence, tandem repeats, C terminus ST rich	513
Hyr1p (deduced 94 kDa)	HYR1	Hyphae	N-terminal signal sequence, C terminus ST rich, GPI anchor sequence	16
Cell wall protein (30 kDa)		Hyphal cell wall, yeast?	Probable posttranslation regulation of location	5
MAb determinants				106
Yeast cell (68, 82, 96, 104 kDa)		Yeast cells and early germ tubes	Proteins have one or two common epitopes
Hyphae (104, 117 kDa)		Germ tubes and hyphal tip	Proteins have one or two common epitopes
Other
Hsp70 (70 kDa)	SSA1 (HSP70), SSA2	Yeast cells, hyphae	Chaperone?, translocation?; immunogenic, Ab protective?	278, 294, 303
Hsp90
47-kDa fragment	HSP90	Yeast cells, hyphae?	hsp90 degradation product, immunogenic, Ab protective	331, 334, 335, 337–340, 342, 532
Enolase (48 kDa)	ENO1-2	Yeast cells, hyphae	Binds to glucan, internal cell wall, lacks N-terminal signal sequence, N terminus blocked, immunogenic, antigen and Abs may be diagnostic, Ab protective?	8, 143, 177, 219, 221, 330, 356, 420, 520–522, 556, 558, 564
Phosphoglycerate kinase (40 kDa)	PGK1	Yeast cells, hyphae	Lacks N-terminal signal sequence, enzymatic activity? immunogenic	6
GAPDH (33 kDa)	TDH1	Yeast cells, hyphae	Enzymatic activity, immunogenic	161
ADH	ADH1?	Cell wall?	Fibronectin binding? immunogenic	27, 406, 489
Als1p	ALS1	Cell wall?	N-terminal signal sequence, variable tandem repeat, GPI-anchor sequence, member family	212, 473

^aAbbreviations: S, serine; T, threonine; Ab, antibody.