Table 2.

Effects and Significance for Primary Hypothesis Testing

PWH Undetectable vs HIV-Negative Controls		PWH Detectable vs HIV-Negative Controls		PWH Detectable vs PWH Undetectable
Effect	P Value	Effect	P Value	Effect	P Value
+0.86 y BAG/decade	.052	+1.5 y BAG/decade	.018*	+0.68 y BAG/decade	.30

The hypothesis of accelerated aging in PWH with detectable VL was tested using an interaction model: BAG ∼ age × group + covariates, with 3 groups: HIV-negative controls, PWH with undetectable VL, and PWH with detectable VL. Effects were quantified as the linear slope of BAG increase per decade. PWH with detectable VL were found to have a significantly faster increase in BAG than controls (P = .018) while those with undetectable VL were not significantly different (P = .052). *P < .05.

Abbreviations: BAG, brain age gap; HIV, human immunodeficiency virus; PWH, persons with HIV; VL, viral load.