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. Author manuscript; available in PMC: 2023 Dec 11.
Published in final edited form as: Cell. 2022 Nov 22;185(25):4801–4810.e13. doi: 10.1016/j.cell.2022.10.024

Figure 4 ∣. AMIO and SOF interact within human Cav1.3 (hCav1.3).

Figure 4 ∣

(A) The overall structure of hCav1.3 bound to AMIO and SOF (hCav1.3AS) is identical to that of rCav1.1AM. The two structures can be superimposed with an RMSD of 0.66 Å for 1782 Cα atoms in the α1 and α2δ-1 subunits. rCav1.1AM is domain colored and hCav1.3AS is colored dark green. (B) SOF and MNI-1 share identical binding pose in the presence of AMIO. Top: A cytosolic view of superimposed α1 subunits from hCav1.3AS and rCav1.1AM. Bottom: Two opposite side views of superimposed α1 subunits from the two structures. (C) Direct interaction of SOF and AMIO within hCav1.3AS. SOF (pink) and MNI-1 (light purple), with similar chemical structures, interact with AMIO in the same way within the PD of LTCCs. See also Figures S4, S5.