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. 2021 Oct 26;113(12):1670–1682. doi: 10.1093/jnci/djab192

Table 3.

Net annualized patient out-of-pocket costs for medical services and prescription drugs by phase of care and stage at diagnosis, SEER-Medicare 2007-2013a,b,c

Service type and cancer site Phase of care
Initial phase
End-of-life cancer death
Localized Regional Distant Localized Regional Distant
Medical services (Medicare Parts A/B)
 Bladder $1244 $2956 $3952 $2634 $3564 $4810
 Breast $2053 $3108 $3711 $2479 $2893 $3677
 Cervix uteri $2221 $3572 $4100 $2770 $3102 $3690
 Colorectal $1755 $3283 $5953 $3000 $3616 $4932
 Esophagus $3379 $5092 $4878 $3914 $4467 $5002
 Kidney $1508 $1993 $3140 $3007 $3449 $4006
 Liver $2742 $2829 $3714 $2647 $2708 $3631
 Lung $2238 $3406 $4567 $2840 $3605 $4756
  NSCLC $2207 $3313 $4542 $2816 $3540 $4755
  SCLC $3514 $4559 $4745 $3274 $4068 $4761
 Melanoma $706 $1636 $2719 $2498 $2892 $4575
 Oral cavity or pharynx $1727 $4044 $4645 $3178 $4154 $4476
 Ovary $1891 $3022 $3565 $2965 $3098 $4086
 Pancreas $3133 $4858 $4646 $3519 $4256 $4571
 Prostated $1834 $1826 $2800 $3047
 Stomach $2358 $4260 $4731 $3289 $4010 $4882
 Thyroid $1149 $1644 $2520 $3094 $3491 $3480
 Uterus $1575 $2769 $3430 $2858 $3278 $3706
 All sites combined $1694 $3194 $3540 $2868 $3604 $4526
Prescription drugs covered through pharmacy benefit (Medicare part D)
 Bladder $154 $146 $195 $248 $143 $226
 Breast $214 $251 $280 $302 $279 $271
 Cervix uteri −$6 −$28 $92 −$53 $44 $32
 Colorectal $64 $48 $115 $94 $94 $102
 Esophagus $415 $235 $444 $193 $169 $341
 Kidney $224 $302 $1713 $627 $979 $1326
 Liver $490 $754 $1435 $591 $1008 $1336
 Lung $325 $408 $787 $484 $513 $618
  NSCLC $324 $417 $851 $499 $550 $687
  SCLC $360 $305 $346 $206 $251 $290
 Melanoma $125 $236 $434 $445 $350 $438
 Oral cavity or pharynx $99 $197 $198 $350 $136 $211
 Ovary −$5 −$11 $221 $289 $50 $145
 Pancreas $449 $796 $1308 $521 $897 $1057
 Prostated $85 $290 $507 $640
 Stomach $291 $221 $596 $120 $134 $268
 Thyroid $222 $232 $316 $745 $434 $218
 Uterus $24 $55 $87 $140 $126 $195
 All sites combined $180 $224 $833 $342 $373 $613
a

Includes patients diagnosed with invasive cancers with information about stage at diagnosis; patients diagnosed with in-situ disease or missing information about stage were excluded from stage-specific analyses. NSCLC = non-small cell lung cancer; SCLC = small cell lung cancer; SEER = Surveillance, Epidemiology, and End Results Program.

b

Costs associated with cancer are estimated as the difference between cancer cases and matched controls. All estimates in 2019 US dollars.

c

Out-of-pocket costs estimated from patient responsibility for medical services (including infusion drugs) under Medicare Parts A/B claims. Out-of-pocket costs for oral prescription drugs estimated directly from Medicare Part D claims.

d

Prostate cancer stage reported as localized or regional during some years of study.