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. 2021 Oct 26;113(12):1670–1682. doi: 10.1093/jnci/djab192

Table 7.

Net patient economic burden associated with cancer in the United States in 2019a

Site Patient out-of-pocket costs by phase of care (in millions)b
Patient time cost (in millions) Patient economic burden (in millions)
Initial Continuing End-of-life cancer death End-of-life other cause of death Total out-of-pocket costs
Bladder $160.3 $440.9 $62.4 $39.1 $702.6 $235.4 $938.0
Breast $955.4 $1937.3 $181.7 $63.4 $3137.8 $1112.2 $4250.0
Cervix $63.0 $82.7 $17.6 $8.6 $172.0 $82.7 $254.6
Colorectal $497.2 $684.4 $221.2 $57.4 $1460.3 $440.6 $1900.9
Hodgkin lymphoma $77.3 $153.6 $9.8 $6.3 $247.0 $70.1 $317.1
Kidney $143.9 $410.3 $75.7 $24.2 $654.1 $164.3 $818.3
Leukemia $145.2 $469.6 $118.2 $25.7 $758.7 $131.8 $890.5
Lung $401.4 $416.2 $490.0 $45.4 $1353.0 $162.8 $1515.8
Melanoma $103.2 $540.1 $43.1 $24.2 $710.6 $394.1 $1104.6
Non-Hodgkin lymphoma $390.2 $611.5 $147.7 $38.1 $1187.5 $218.8 $1406.3
Oral cavity or pharynx $171.3 $161.8 $78.9 $18.1 $430.0 $109.8 $539.9
Ovary $101.7 $195.8 $74.2 $6.1 $377.8 $72.2 $450.0
Prostate $805.2 $1234.1 $125.2 $97.3 $2261.8 $1035.5 $3297.3
Thyroid $138.3 $499.7 $11.8 $12.6 $662.4 $265.5 $927.8
Corpus uterine $171.0 $256.8 $47.8 $17.6 $493.2 $231.2 $724.5
All sites combined $4718.8 $8878.2 $2101.5 $521.4 $16219.9 $4873.6 $21093.6
a

National cancer prevalence estimates by age group, phase of care, and cancer site combined with annualized patient out-of-pocket costs from Surveillance, Epidemiology, and End Results Program-Medicare and annual patient time costs from the Medical Expenditure Panel Survey (MEPS).

b

Out-of-pocket costs estimated from patient responsibility for medical services (including infusion drugs) under Medicare Parts A/B claims. Out-of-pocket costs for oral prescription drugs estimated directly from Medicare Part D claims. Estimates from the MEPS in Table 5 were used to incorporate higher out-of-pocket spending in younger age group for medical services ($232.7 vs $97.7) and prescription drugs ($87.4 vs $67.0), yielding ratios of 2.38 and 1.30, respectively. All estimates are in 2019 US dollars.