FIG. 1.

Protein transport pathways to the yeast vacuole. Depicted are six pathways used by proteins to reach the vacuole in S. cerevisiae: 1, sorting of vacuolar proteins in the late Golgi (a) through a PVC and (b) via an alternative route; 2, endocytosis of proteins from the cell surface; 3, biosynthetic cytoplasm to vacuolar targeting; 4, autophagy (degradative cytoplasm to vacuolar targeting); 5, vacuolar inheritance from mother to daughter cells, using homotypic fusion to fuse vacuolar vesicles.