Table 1.
Deduplicated abundance 1 |
Deduplicated abundance 2 |
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Dataset | Methods | Hap1 | Hap2 | SD | Jaccard | Ruzicka | Hap1 | Hap2 | SD | Jaccard | Ruzicka | ||||
V1V2 | Calib | 808 | 797 | (21) | 0.08 | (0.00) | 0.23 | (0.00) | 43 | 43 | (4) | 0.67 | (0.03) | 0.82 | (0.02) |
DAUMI | 90 | 90 | (5) | 0.72 | (0.03) | 0.84 | (0.02) | 37 | 37 | (2) | 0.77 | (0.05) | 0.87 | (0.02) | |
Naïve | 293 | 303 | (9) | 0.29 | (0.01) | 0.57 | (0.01) | 43 | 43 | (3) | 0.75 | (0.03) | 0.88 | (0.03) | |
Starcode-umi | 2304 | 2311 | (48) | 0.00 | (0.00) | 0.19 | (0.00) | 15 | 13 | (1) | 0.73 | (0.05) | 0.80 | (0.02) | |
UMI-tools | 542 | 538 | (16) | 0.14 | (0.00) | 0.36 | (0.00) | 42 | 42 | (3) | 0.77 | (0.04) | 0.87 | (0.01) | |
V3 | Calib | 5048 | 5021 | (57) | 0.06 | (0.00) | 0.11 | (0.00) | 64 | 66 | (4) | 0.55 | (0.04) | 0.71 | (0.02) |
DAUMI | 180 | 171 | (7) | 0.39 | (0.01) | 0.72 | (0.01) | 68 | 72 | (4) | 0.72 | (0.03) | 0.83 | (0.01) | |
Naïve | 1561 | 1543 | (10) | 0.06 | (0.00) | 0.22 | (0.00) | 91 | 84 | (4) | 0.64 | (0.04) | 0.74 | (0.02) | |
Starcode-umi | 15077 | 15097 | (79) | 0.02 | (0.00) | 0.09 | (0.00) | 96 | 103 | (5) | 0.08 | (0.01) | 0.77 | (0.02) | |
UMI-tools | 3718 | 3724 | (36) | 0.06 | (0.00) | 0.14 | (0.00) | 72 | 74 | (3) | 0.64 | (0.03) | 0.75 | (0.01) |
Note: The mean and standard deviation (SD in parentheses) of five replicates of: Hap1 and Hap2: no. inferred haplotypes in each subset (rounded to integer); Jaccard: Jaccard Index of inferred haplotype sets; Ruzicka: Ruzicka Similarity, abundance-weighted form of Jaccard Index. For DAUMI, ρ = 10 for V3, ρ = 7 for V1V2, both subsets. Best performance is bolded per dataset.