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. 2022 Nov 23;34(3):422–430. doi: 10.1097/CAD.0000000000001445

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Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.

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Fig. 3 — Resistant CAFs-derived exosomes deliver VEGFA. Resistant CAFs-derived exosomes (Resistant CAFs-Exo) and Sensitive CAFs-derived exosomes (Sensitive CAFs-Exo) were isolated, then the angiogenesis-related factors were detected. (a) qRT-PCR was used to detect the mRNA expression of related factors. (b) Western blot was performed for the detection of related factors. (c) Immunofluorescence assay was used to detect the expression of VEGFA. *P < 0.05; **P < 0.01; ***P < 0.001. CAFs, cancer-associated fibroblasts.