Extended Data Fig. 8. Complete results of correlations between scDRS disease scores and inferred spatial coordinates across CA1 pyramidal neurons in 7 single-cell data sets (extending results in Figure 5b).

(a) Results for regressing the scDRS disease scores against the inferred spatial coordinates for each disease/trait and each inferred spatial coordinate. Color represents the t-statistics and stars represent significant associations (* denotes P<0.05 and ** denotes P<0.005, one-sided MC test; Methods). For clarification, Zeisel & Muñoz-Manchado et al. refers to the data from Zeisel & Muñoz-Manchado et al. 2015 Science⁴⁶ and Zeisel et al. refers to the data from Zeisel et al. 2018 Cell⁵¹. (b) Summary of results in panel a. Heatmap color represent the average t-statistics across the 7 brain-related diseases/traits (excluding height) for each data set and stars represent significant associations by combining p-values across datasets using Fisher’s combined probability test. (c) Summary of the association between brain-related diseases and the inferred spatial coordinates for the mouse and human data sets in panel b.