Ali 2021.
| Study characteristics | ||
| Methods | RCT | |
| Participants | N = 40 (23F/17M) Confirmed clinical diagnosis of mild or moderate dementia in adults (aged 40 and over) with premorbid mild or moderate intellectual disability Age 60.4 (SD 8.2) Most (72.5%) living in supported housing/residential care 45% receiving anti‐dementia medication |
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| Interventions | Individual cognitive stimulation delivered by carers (N = 20) (most carers (82.5%) were paid carers; remainder are relatives or friends) Waiting‐list controls receiving usual treatment (N = 20) |
|
| Outcomes | Cognition: Cambridge Cognitive Examination for Older Adults with Down Syndrome (CAM‐COG‐DS); Modified Memory for
Objects tests from Neuropsychological Assessment of Dementia in Intellectual Disabilities Battery; Cognitive Scale for Down Syndrome (CSDS) (proxy‐completed) Quality of life: QoL‐AD (proxy‐completed) ADL: Alzheimer’s Dementia Cooperative Study‐Activities of Daily Living Inventory (ADCS‐ADL) Caregiver outcomes: Care Giving Burden Scale; Sense of Competence in Dementia Care Staff Scale (SCIDS); Hospital Anxiety and Depression Scale (HADS) |
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| Notes | Recommended 30 minutes, twice a week, for 20 weeks | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | "The randomisation process was performed centrally using a web‐based system". |
| Allocation concealment (selection bias) | Low risk | Randomisation carried out by external administrator and unblinded researcher informed participants of allocation. |
| Blinding of outcome assessment (detection bias) All outcomes | Low risk | Blinded evaluator |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | Low attrition at end‐point and intention‐to‐treat analyses reported |
| Selective reporting (reporting bias) | Low risk | All outcomes cited in protocol paper appeared to be reported. |
| Other bias ‐ training and supervision | Low risk | One‐to‐one training and ongoing support provided to carers implementing the intervention |
| Other bias ‐ treatment manual | Low risk | Used adapted version of iCST Manual (Yates 2014) |