Buschert 2011.
Study characteristics | ||
Methods | RCT | |
Participants | N = 39 24 amnestic MCI; 15 mild Alzheimer's disease (only data on Alzheimer's patients reported in this review) 8F/7M Mean MMSE 24.9 (SD 1.6; range 22‐27) All on stable doses of AChEIs or memantine Age 75.9 (SD 8.1) Outpatients |
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Interventions | Multi‐component cognitive group intervention ‐ for AD group (N = 8) emphasis on cognitive stimulation (for MCI group more emphasis on cognitive training); Control group (N = 7) had pencil and paper exercises for self‐study and monthly meetings. | |
Outcomes | Cognition: MMSE; ADAS‐Cog, Trail Making Test, RBANS story memory & recall Quality of life: QoL‐AD Mood: Montgomery Asberg Depression Rating Scale |
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Notes | 2 hours, once a week for 6 months (20 sessions) | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Blocked randomisation procedure; participants pooled in pairs with respect to age, gender, education and ApoE genotype, then randomly assigned pairs to intervention or control using a computerised random number generator |
Allocation concealment (selection bias) | Low risk | Blocked randomisation procedure ‐ "a study‐independent person then randomly assigned pairs to the intervention or control arm". |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Assessors blind to group allocation |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Zero attrition in AD group |
Selective reporting (reporting bias) | Low risk | Data on all measures reported |
Other bias ‐ training and supervision | Unclear risk | No information provided regarding training or supervision of the group leader, who remained constant throughout (first author) |
Other bias ‐ treatment manual | Low risk | "Manual with reproducible detailed protocols" developed before start of programme |