Cove 2014.
Study characteristics | ||
Methods | RCT | |
Participants | N = 47 (22F/25M) DSM‐IV criteria for dementia of any type (62% Alzheimer's or mixed) 62% receiving dementia medications Mean MMSE 22.8 (SD 3.4) Age 77.3 (SD 7.0) Living in the community |
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Interventions | CST groups + carer training (N = 21) CST groups (N = 24) Waiting‐list controls (N = 23) |
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Outcomes | Cognitive: MMSE, ADAS‐Cog Quality of Life: QoL‐AD Quality of Caregiver‐Patient Relationship (QCPR) |
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Notes | Comparison of interest was CST groups versus controls; 45 minutes, once a week for 14 weeks. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | "Participants were randomized using the block method to achieve equal group sizes using Random Allocation Software". |
Allocation concealment (selection bias) | Low risk | Although randomisation appeared to have preceded baseline assessment, it seemed to be independent of assessment. |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Assessors clearly blinded |
Incomplete outcome data (attrition bias) All outcomes | Low risk | 3/24 withdrew from CST and 2/24 from controls, but ITT analysis used (LOCF). 1 person withdrew from controls before assessment, and was not included, but probably minimal effect. |
Selective reporting (reporting bias) | Low risk | All outcomes reported |
Other bias ‐ training and supervision | Unclear risk | Groups run by clinicians ‐ no mention of training or supervision |
Other bias ‐ treatment manual | Low risk | The study followed the standardised CST manual (Spector 2006). |