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. 2023 Jan 31;2023(1):CD005562. doi: 10.1002/14651858.CD005562.pub3

Cove 2014.

Study characteristics
Methods RCT
Participants N = 47 (22F/25M)
DSM‐IV criteria for dementia of any type (62% Alzheimer's or mixed)
62% receiving dementia medications
Mean MMSE 22.8 (SD 3.4)
Age 77.3 (SD 7.0)
Living in the community
Interventions CST groups + carer training (N = 21)
CST groups (N = 24)
Waiting‐list controls (N = 23)
Outcomes Cognitive: MMSE, ADAS‐Cog
Quality of Life: QoL‐AD
Quality of Caregiver‐Patient Relationship (QCPR)
Notes Comparison of interest was CST groups versus controls; 45 minutes, once a week for 14 weeks.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk "Participants were randomized using the block method to achieve equal group sizes using Random Allocation Software".
Allocation concealment (selection bias) Low risk Although randomisation appeared to have preceded baseline assessment, it seemed to be independent of assessment.
Blinding of outcome assessment (detection bias)
All outcomes Low risk Assessors clearly blinded
Incomplete outcome data (attrition bias)
All outcomes Low risk 3/24 withdrew from CST and 2/24 from controls, but ITT analysis used (LOCF). 1 person withdrew from controls before assessment, and was not included, but probably minimal effect.
Selective reporting (reporting bias) Low risk All outcomes reported
Other bias ‐ training and supervision Unclear risk Groups run by clinicians ‐ no mention of training or supervision
Other bias ‐ treatment manual Low risk The study followed the standardised CST manual (Spector 2006).