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. 2023 Jan 31;2023(1):CD005562. doi: 10.1002/14651858.CD005562.pub3

Justo‐Henriques 2022.

Study characteristics
Methods RCT
Participants N = 59 (36F/23M)
Formal diagnosis of a neurocognitive disorder according to DSM‐5 criteria (51% Alzheimer's disease)
No details available regarding AChEI medication
Mean MMSE: 23.2 (SD 3.2)
Age 78.9 (SD; 7.5; range 65‐98)
Community
Interventions Home‐based Individual cognitive stimulation delivered by clinical psychologist (N = 30)
Treatment‐as‐usual (N = 29)
Outcomes Cognition: MoCA, MMSE
Quality of life: QoL‐AD (self‐report)
Mood: GDS‐15
ADL: adapted Lawton‐Brody Index
Notes 45 minutes, once a week, for 47 weeks
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk "Non‐stratified permuted block randomization process" carried out by blinded investigator using computer software
Allocation concealment (selection bias) Low risk "Allocation was unknown to participants and the therapist until the intervention started".
Blinding of outcome assessment (detection bias)
All outcomes Low risk Evaluator blinded to participant allocation
Incomplete outcome data (attrition bias)
All outcomes Unclear risk Relatively high level of attrition (8/30 in intervention group), but lengthy treatment period (47 weeks) and reasons given. Similar attrition in control group
Selective reporting (reporting bias) Low risk Results for all outcomes cited in Methods section were reported.
Other bias ‐ training and supervision Low risk Experienced therapist received additional training.
Other bias ‐ treatment manual Low risk The study protocol provided a detailed account of the activities for each session.