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. 2023 Jan 31;2023(1):CD005562. doi: 10.1002/14651858.CD005562.pub3

Kim 2016.

Study characteristics
Methods RCT
Participants N = 53 (37F/16M)
Probable Alzheimer's Disease (NINCDS and ADRDA criteria)
All participants receiving 'pharmacotherapy' for dementia
Mean MMSE 18.0 (SD 5.8)
Age 78.5 (SD 1.5; range 61‐94)
Community residents attending dementia centre
Interventions Multi‐domain cognitive stimulation (N = 32)
Control group (N = 21)
Outcomes Cognition: CERAD (Korean version), including word fluency; short Boston naming test; tests of praxis, recall and recognition; MMSE
Mood: Geriatric Depression Scale
Quality of Life: QoL‐AD (Korean version) (self‐rated and proxy)
Clinical Dementia Rating Scale
Notes 1 hour, 5 times a week for 6 months
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Description of randomisation unclear ('using random numbering')
Allocation concealment (selection bias) Unclear risk No mention of randomisation being carried out independently
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk No information about blinding
Incomplete outcome data (attrition bias)
All outcomes High risk No attrition from intervention group; 34% attrition from control group
Selective reporting (reporting bias) Low risk All outcome measures mentioned in methods were reported.
Other bias ‐ training and supervision Low risk "Implementation and management of the cognitive intervention program were carried out by two skilled and professionally educated occupational therapists."
Other bias ‐ treatment manual Low risk Clear structure for the intervention