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. 2023 Jan 31;2023(1):CD005562. doi: 10.1002/14651858.CD005562.pub3

Lok 2020.

Study characteristics
Methods RCT
Participants N = 60 (30F/30M)
Typical Alzheimer's disease in accordance with International Working Group‐2 diagnostic criteria
All receiving AChEI medication
Mean MMSE 16.9 (SD 4.3)
Age ‐ no information provided
Community residents
Interventions CST groups based on Roy's adaptation model (RAM) (N = 30)
Treatment‐as‐usual controls (N = 30)
Outcomes Cognition: Standardised MMSE
Quality of Life: QoL‐AD
Coping and Adaptation Processing Scale (CAPS)
Notes 45 minutes, twice a week for 7 weeks
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Electronic randomisation programme used
Allocation concealment (selection bias) Unclear risk No information about allocation concealment and independence of randomisation
Blinding of outcome assessment (detection bias)
All outcomes High risk "Pre‐test and post‐test data were collected and RAM‐based CST was applied by the same person".
Incomplete outcome data (attrition bias)
All outcomes Low risk Attrition reported as zero and no cases were excluded from analysis
Selective reporting (reporting bias) Low risk All outcome measures mentioned in methods were reported.
Other bias ‐ training and supervision Unclear risk Intervention delivered by first author of the paper but little information about receiving training in CST
Other bias ‐ treatment manual Low risk Based on the manualised CST programme (Spector 2006)