Lopez 2020.

Study characteristics
Methods	RCT
Participants	N = 20 (15F/5M) Alzheimer's dementia according to DSM‐5 criteria All receiving AChEI medication Mean MMSE 17.9 (SD 3.9) Age 81.9 (SD 5.5; range 66‐89) Community ‐ daycare centre
Interventions	Cognitive stimulation groups (N = 10) Treatment‐as‐usual controls (N = 10)
Outcomes	Cognition: ADAS‐Cog; MMSE; WAIS‐III, Wechsler Memory Scale III and Neuropsychological test battery (32 tests in total), including verbal fluency, digit span, Boston Naming Test
Notes	60 minutes, three times a week for 6 months
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Sequence of block randomisation was described.
Allocation concealment (selection bias)	Unclear risk	No information about blinding at point of randomisation
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information about blinding of outcome assessments
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	There was no indication of attrition, despite being a 6‐month intervention study.
Selective reporting (reporting bias)	Low risk	All outcome measures mentioned in methods were reported.
Other bias ‐ training and supervision	Unclear risk	Little to no information about who delivered the intervention
Other bias ‐ treatment manual	Low risk	Intervention was extracted from a manualised, Spanish cognitive psychostimulation therapy (cuadernos de repaso).