Maci 2012.

Study characteristics
Methods	RCT
Participants	N = 14 (8F/6M) Alzheimer's Disease, according to National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer’s Disease and Related Disorders Association (NINCDS‐ADRDA) criteria All receiving a stable dose regimen of memantine and/or cholinesterase inhibitors and/or antidepressants for at least 6 months prior to the beginning of the study Mean MMSE 17.8 (SD 2.8) Age 72.6 (SD 9.5) Community (gymnasium)
Interventions	Cognitive stimulation/physical activity groups (N = 7) Treatment‐as‐usual (N = 7)
Outcomes	Cognition: MMSE; Frontal Assessment Battery Clinical Dementia Rating ADL: Katz ADL scale; Lawton & Brody Instrumental Activities of Daily Living scale Mood: Cornell Scale for Depression in Dementia; Hamilton Anxiety Rating Scale Quality of Life: Cornell‐Brown Scale for Quality of life in Dementia; Apathy Evaluation Scale; Quality of Life–Alzheimer’s Disease (QoL‐AD; self‐report and caregiver proxy) Family caregiver outcomes: Caregiver Burden Inventory; Beck Depression Inventory
Notes	120 minutes, five times a week for 3 months
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"Randomly assigned to the active treatment group or to the usual care as control group according to a list of randomly generated sequence of numbers."
Allocation concealment (selection bias)	Unclear risk	No indication of who carried out randomisation or their independence
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Examiners blinded
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No mention of attrition ‐ none reported over 3‐month period?
Selective reporting (reporting bias)	Low risk	All outcomes appear to be reported.
Other bias ‐ training and supervision	Low risk	Training and supervision provided
Other bias ‐ treatment manual	Low risk	There was a clear structure, though no indication of a manual as such.