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. 2023 Jan 31;2023(1):CD005562. doi: 10.1002/14651858.CD005562.pub3

Marinho 2021.

Study characteristics
Methods RCT
Participants N = 47 (29F/18M)
Clinical diagnosis of dementia according to DSM‐IV criteria (MMSE 10‐24)
All participants receiving AChEI medication
Clinical Dementia Rating: 23 mild; 24 moderate
Age 77.8 (SD; 8.4; range 60‐91)
Outpatients
Interventions Cognitive stimulation groups (N = 23)
Treatment‐as‐usual (N = 24)
Outcomes Cognition: ADAS‐Cog
Quality of life: QoL‐AD (self‐report and proxy)
Mood: Cornell Scale for Depression in Dementia
ADL: ADCS‐ADL scale
Caregiver outcomes: Zarit Burden Interview
Notes 45 minutes, 2 times a week, for 7 weeks (both weekly sessions on same day, separated by short break)
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Used a random list generated by a computer program; stratified by dementia severity
Allocation concealment (selection bias) Unclear risk Not detailed who carried out the randomisation, and whether external to the study
Blinding of outcome assessment (detection bias)
All outcomes Low risk Outcome assessments carried out by researchers blind to the intervention
Incomplete outcome data (attrition bias)
All outcomes Low risk Data provided for intention‐to‐treat analysis; reasons for dropouts described
Selective reporting (reporting bias) Low risk Results for all outcomes reported
Other bias ‐ training and supervision Low risk Facilitators trained by International CST centre
Other bias ‐ treatment manual Low risk Used Brazilian CST manual, adapted from Spector 2006